Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability
Authors:
- Bernard MulveyBMBernard Mulvey
- Heena R. DivechaHDHeena R. Divecha
- Madhavi TippaniMTMadhavi Tippani
- Svitlana V. BachSBSvitlana V. Bach
- Rahul BharadwajRBRahul Bharadwaj
- Ishbel Del RosarioIRIshbel Del Rosario
- Sarah E. MaguireSMSarah E. Maguire
- Ryan A. MillerRMRyan A. Miller
- Aaron J. SalisburyASAaron J. Salisbury
- Atharv ChandraACAtharv Chandra
- Beau A. OsterBOBeau A. Oster
- Kelsey D. MontgomeryKMKelsey D. Montgomery
- 11 September 2026
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 152 (1) , 32
Abstract
No abstract availableKeywords
Funding Information
- National Institutes of Health (T32MH015330)
- National Institutes of Health (R01AG085933)
- Carol and Gene Ludwig Award for Neurodegeneration Research
This publication has 186 references indexed in Scilit:
- Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigraAlzheimer's & Dementia, 2025
- Locus coeruleus tau is linked to successive cortical tau accumulationAlzheimer's & Dementia, 2024
- Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early‐ and late‐onset Alzheimer's diseaseAlzheimer's & Dementia, 2024
- Sex and gender differences in cognitive resilience to aging and Alzheimer's diseaseAlzheimer's & Dementia, 2024
- Associations of 24‐Hour Rest‐Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's DiseaseAnnals of Neurology, 2024
- Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older AdultsJAMA Neurology, 2023
- Ancestry‐related differences in chromatin accessibility and gene expression of APOE ε4 are associated with Alzheimer's disease riskAlzheimer's & Dementia, 2023
- Association of Race and Ethnicity With Incidence of Dementia Among Older AdultsJAMA, 2022
- Increased activity of surviving locus ceruleus neurons in Alzheimer's diseaseAnnals of Neurology, 1999
- The protective influence of the locus ceruleus on the blood‐brain barrierAnnals of Neurology, 1984