Kidney Storage at Subzero Temperatures Using a Hyperosmolar Perfusate

Authors:
  • RGR. Grundmann
    R. Grundmann
  • BKB. Kaemmerer
    B. Kaemmerer
  • DHD. Helling
    D. Helling
  • HPH Pichlmaier
    H Pichlmaier
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Abstract
32 dog kidneys were stored in a hyperosmolar perfusate (770 mosm/kg) at –2 and +4 °C, respectively, for 12–48 h and thereafter autotransplanted. 18 kidneys of the control group were stored in Collins solution at +4 °C. The immediate function of the kidneys after transplantation was measured by p-aminohippuric acid and inulin clearances. Successful 24-hour preservation was possible by use of the hyperosmolar perfusate. Kidneys stored in the hyperosmolar perfusate at –2 °C were better preserved than kidneys stored in Collins solution at +4 °C. The addition of human albumin to the hyperosmolar perfusate did not improve the preservation results.