Effect of astemizole on psychomotor performance in healthy thais

Authors:
Publisher website
Google Scholar
Abstract
The absence of CNS‐related side effects of astemizole, a new long‐acting specific histamine, H1‐antagonist, has been reported by many authors. To investigate the influence of this new antihistamine on psychomotor performance in Thais, oral therapeutic doses of 10 mg once daily were administered for 7 days to 21 healthy Thai volunteers (13 males and eight females). Ages ranged from 22 to 37 years and body weights from 40 to 65 kg. The study used a double‐blind crossover design. Subjective assessments were carried out by means of a visual analogue rating scale and a four‐point alertness rating scale and objective assessments by means of card sorting, glass bead picking, and recording of reaction times for visual stimuli in a choice situation. Compared to placebo, astemizole caused no change in any of the ratings or performances at either 1 or 2 h subsequent to the first and last (i.e., seventh) dose. It might thus be concluded that astemizole is free of CNS‐depressant effects in Thai volunteers.

This publication has 1 reference indexed in Scilit: