Infection Rates of Rifampin/Gentamicin-Coated Titan Coloplast Penile Implants. Comparison with Inhibizone-Impregnated AMS Penile Implants

Authors:
Publisher website
Google Scholar
Abstract
Introduction: It is a common practice to soak Titan® Coloplast penile implants in antibiotic solution prior to implantation. Experience with Inhibizone impregnation suggests that rifampin coating significantly reduces infection rates of penile implant surgery. In this article we describe the results of coating Titan Coloplast penile implants with rifampin/gentamicin solution. Aim: To compare infection rates of Titan® Coloplast penile implants coated with vancomycin/gentamycin, rifampin/gentamicin, and Inhibizone-impregnated American Medical Systems (AMS) penile implants. Methods: Chart review was done for all Mentor/Coloplast and AMS implant surgeries performed at our center between the dates January 1, 2002 and February 8, 2010. Infection rates for Titan® Coloplast penile implants coated with vancomycin/gentamycin, rifampin/gentamicin, and Inhibizone-impregnated (AMS) penile implants were compared. Main Outcome Measures: Infection rates for penile implants coated with different antibiotics. Results: Infection rates for Titan® Coloplast penile implants coated with vancomycin/gentamycin and Inhibizone-impregnated (AMS) penile implants was 4.4% and 1.3%, respectively (P = 0.05). None of the rifampin/gentamicin-coated Titan® Coloplast penile implants have developed infection. Rifampin is the common antibiotic both in rifampin/gentamicin-coated Coloplast implants and Inhibizone®. The infection rate in this combined rifampin/gentamicin-coated Titan Coloplast implants and Inhibizone-coated AMS implants group was 0.63% (P = 0.03). Conclusion: Both rifampin/gentamicin-coated Titan® Coloplast penile implants and Inhibizone-impregnated (AMS) penile implants appear to have lower infection rates compared with vancomycin/gentamycin-coated Titan® Coloplast penile implants The present study does not suggest superiority of rifampin/gentamicin-coated Titan® Coloplast penile implants or Inhibizone-impregnated (AMS) penile implants but we strongly suggest that all Titan® Coloplast penile implants should be coated with rifampin/gentamicin solution.

This publication has 13 references indexed in Scilit: