The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19
Authors:
- 1 July 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 67 (2) , 174-177
Abstract
We used a cloned human cDNA probe homologous to the placenta chorionic gonadotropin β subunit (CGB) and to the pituitary luteinizing hormone β subunit (LHB) and Southern blotting techniques to analyse DNA from a series of rodent x human somatic cell hybrids for the presence of specific gonadotropin β subunit related sequences. Our results provide evidence for the assignment and linkage of the eight genes (or pseudogenes) coding for the β subunit of these glycoprotein hormones to chromosome 19. Moreover, we observed a strict concordance between the permissivity of mouse x man hybrid cells to enteroviruses (which is linked to the presence of specific cell receptors encoded by human chromosome 19) and the presence of CGB and LHB related sequences, thus confirming the localization of the structural genes for the β subunits on chromosome 19.Keywords
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