The effect of Indomethacin on the anterior segment of the eye after paracentesis

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Abstract
The prostaglandin-inhibiting effect of Indomethacin (IN) was studied in rabbits, using paracentesis as a stimulus and rise in aqueous protein and fluorescein concentration after intravenous fluorescein injection as parameters. In eyes pre-treated with IN eye-drops the rise in fluorescein and protein concentration in the secondary aqueous was less than in the control eyes; the rise in the control eyes was less than in the eyes of rabbits not treated with IN. There was a good correlation between the rise in protein and the rise in fluorescein concentration in the secondary aqueous. The four different 0.5% IN suspensions used showed different PG-inhibiting activity, attributed to the difference in physicochemical composition.