Responsiveness of Jaw Motor Activation to Arousals during Sleep in Patients with Obstructive Sleep Apnea Syndrome
Authors:
- Takafumi KatoTKTakafumi Kato
- Takeshi KataseTKTakeshi Katase
- Shuichiro YamashitaSYShuichiro Yamashita
- Hideko SugitaHSHideko Sugita
- Hisae MurakiHMHisae Muraki
- Akira MikamiAMAkira Mikami
- Mutsumi OkuraMOMutsumi Okura
- Motoharu OhiMOMotoharu Ohi
- Yuji MasudaYMYuji Masuda
- Mitsutaka TaniguchiMTMitsutaka Taniguchi
- 15 August 2013
- journal article
- Published by Springer Nature in Journal of Clinical Sleep Medicine
- Vol. 9 (8) , 759-765
Abstract
We aimed to characterize the association between jaw muscle contractions and respiratory events in patients with obstructive sleep apnea syndrome (OSAS) and to investigate the responsiveness of the contractions to respiratory events in comparison with that of leg muscles in terms of arousal types and sleep states. Polysomnographic (PSG) recordings were performed in 19 OSAS patients (F/M: 2/17; 53.1 ± 13.7 years; AHI: 31.8 ± 19.9/h) with no concomitant sleep bruxism or other sleep-related movement disorders. Muscle contractions of unilateral masseter (MAS) and anterior tibialis (AT) muscles were scored during sleep in association with graded arousals (microarousals and awakenings) related or unrelated to apneahypopnea events. Arousals were scored for 68.2% and 52.3% of respiratory events during light NREM and REM sleep, respectively. Respiratory events with arousals were associated with longer event duration and/or larger transient oxygen desaturation than those without (ANOVAs: p < 0.05). Median response rates of MAS events to respiratory events were 32.1% and 18.9% during NREM and REM sleep. During two sleep states, MAS muscle was rarely activated after respiratory events without arousals, while its response rate increased significantly in association with the duration of arousals (Friedman tests: p < 0.001). A similar response pattern was found for AT muscle. Motor responsiveness of the two muscles to arousals after respiratory events did not differ from responsiveness to spontaneous arousals in two sleep stages. In patients with OSAS, the contractions of MAS and AT muscles after respiratory events can be nonspecific motor phenomena, dependent on the duration of arousals rather than the occurrence of respiratory events.Keywords
This publication has 40 references indexed in Scilit:
- The relationship between mouth opening and sleep stage-related sleep disordered breathing.2011
- Assessment of mastication with implications for oral rehabilitation: a reviewJournal of Oral Rehabilitation, 2011
- Heterogeneous activity level of jaw-closing and -opening muscles and its association with arousal levels during sleep in the guinea pigAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010
- Iron Stores, Periodic Leg Movements, and Sleepiness in Obstructive Sleep ApneaJournal of Clinical Sleep Medicine, 2009
- Side effects of boil and bite type oral appliance therapy in sleep apnea patientsSleep and Breathing, 2009
- Apnoea–Hypopnoea Index during Rapid Eye Movement and Non-Rapid Eye Movement Sleep in Obstructive Sleep ApnoeaJournal of International Medical Research, 2008
- On the potential clinical relevance of the length of arousals from sleep in patients with obstructive sleep apnea.2006
- Long-Term Compliance and Side Effects of Oral Appliances Used for the Treatment of Snoring and Obstructive Sleep Apnea SyndromeJournal of Clinical Sleep Medicine, 2005
- Effect of CPAP treatment on inspiratory arousal threshold during NREM sleep in OSASSleep and Breathing, 2005
- INSPIRATORY MUSCLE-ACTIVITY AS A TRIGGER CAUSING THE AIRWAYS TO OPEN IN OBSTRUCTIVE SLEEP-APNEA1987