Rifabutin central nervous system concentrations in a rabbit model of tuberculous meningitis
Open Access
- 7 August 2024
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 68 (8) , e0078324
Abstract
Tuberculous meningitis (TBM) has a high mortality, possibly due to suboptimal therapy. Drug exposure data of antituberculosis agents in the central nervous system (CNS) are required to develop more effective regimens. Rifabutin is a rifamycin equivalently potent to rifampin in human pulmonary tuberculosis. Here, we show that human-equivalent doses of rifabutin achieved potentially therapeutic exposure in relevant CNS tissues in a rabbit model of TBM, supporting further evaluation in clinical trials.Keywords
Funding Information
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI145436)
- HHS | National Institutes of Health (K43TW011421,U01AI170426)
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