Proteasomal activity modulates TGF‐ß signaling in a gene‐specific manner
Authors:
- Marikki LaihoMLMarikki Laiho
- 14 August 2002
- journal article
- Published by Wiley in FEBS Letters
- Vol. 527 (1-3) , 58-62
Abstract
Transforming growth factor-β (TGF-β) signaling relies on Smad-signaling pathway controlled in part by the proteasome. Here we demonstrate that inhibition of the proteasome function in mink epithelial cells accumulates both positive and negative modulators of TGF-β signaling, phospho-Smad2 and SnoN. Inhibition of the proteasome led to abrogation of TGF-β target gene regulation in a gene-specific manner. While regulation of p15Ink4b and myc by TGF-β are lost, PAI-1 induction, previously shown to occur in a Smad3-dependent manner, was not affected by treatment of the cells with the proteasomal inhibitor MG132. The results suggest that proteasomal activity is required for TGF-β signaling in a gene-specific mannerKeywords
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