Functionalizable low-fouling coatings for label-free biosensing in complex biological media: advances and applications
- 29 March 2015
- journal article
- review article
- Published by Springer Nature in Analytical and Bioanalytical Chemistry
- Vol. 407 (14) , 3927-3953
Abstract
This review focuses on recent advances in the development of functionalizable antifouling coatings and their applications in label-free optical biosensors. Approaches to the development of antifouling coatings, ranging from self-assembled monolayers and PEG derivatives to ultra-low-fouling polymer brushes, are reviewed. Methods of preparation and characterization of antifouling coatings and the functionalization of antifouling coatings with bioreceptors are reviewed, and the effect of functionalization on the fouling properties of biofunctional coating is discussed. Special attention is given to biofunctional coatings for label-free bioanalysis of blood plasma and serum for medical diagnostics.Keywords
This publication has 226 references indexed in Scilit:
- Directly Functionalizable Surface Platform for Protein Arrays in Undiluted Human Blood PlasmaAnalytical Chemistry, 2013
- Controlled/Living Surface‐Initiated ATRP of Antifouling Polymer Brushes from Gold in PBS and Blood Sera as a Model Study for Polymer Modifications in Complex Biological MediaMacromolecular Bioscience, 2012
- Ultra-low fouling and functionalizable zwitterionic coatings grafted onto SiO2 via a biomimetic adhesive group for sensing and detection in complex mediaBiosensors and Bioelectronics, 2010
- Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scaleBiomaterials, 2010
- Ultralow‐Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological ApplicationsAdvanced Materials, 2010
- Plasma Process. Polym. 2/2010Plasma Processes and Polymers, 2010
- Protein and Electrode Engineering for the Covalent Immobilization of P450 BMP on GoldAnalytical Chemistry, 2008
- Sensitive optical biosensors for unlabeled targets: A reviewAnalytica Chimica Acta, 2008
- Reversible oriented immobilization of histidine-tagged proteins on gold surfaces using a chelator thioalkaneSupramolecular Science, 1995
- Preadsorption of polymers on glass and silica to reduce fibrinogen adsorptionJournal of Biomedical Materials Research, 1989