Visible‐Light‐Induced Deaminative Alkylation for the Synthesis of Chroman‐4‐One Derivatives via EDA Complexes
- 31 October 2024
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 367 (2)
Abstract
A visible‐light‐mediated synthesis of 3‐alkyl‐ substituted chroman‐4‐one derivatives via deaminative alkylation of amino acid derived Katritzky salts and tandem cyclization with o‐(allyloxy)arylaldehydes has been developed. This approach exhibits functional‐group compatibility with 31 examples and affords the desired products in yields of 16–88%. Mechanistic research results suggest that the formation of EDA complexes between the Katritzky salts and a base is the main reason for initiating the reaction.Keywords
Funding Information
- National Natural Science Foundation of China (21172200)
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