Direct Catalytic Stereoselective Synthesis of C4′ Functionalized Furanoside and Nucleoside Derivatives with a Tetrasubstituted Stereocenter
Authors:
Open Access
- 9 April 2024
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 366 (10) , 2370-2375
Abstract
A direct catalytic stereoselective synthesis of C4’ functionalized furanoside and nucleoside derivatives with a tetrasubstituted stereocenter is disclosed. The amine‐catalyzed stereoselective α‐aminomethylation reactions on furanoside‐derived aldehyde derivatives gave the corresponding C4’ functionalized D‐ or L‐ribose derivatives in good to excellent yields (67−94%) with up to >20:1 dr.Keywords
Funding Information
- Mittuniversitetet
- European Commission (20202581)
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