Giant oesophageal liposarcoma mimicking spindle cell liposarcoma and containing eosinophilic cells with rhabdomyoblastic differentiation

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Abstract
An-83-year-old Japanese man presenting with chest discomfort and vomiting was admitted to our hospital. Upper gastrointestinal endoscopy and radiological examinations showed a giant submucosal tumour in the thoracic oesophagus. Consecutive subtotal oesophagectomy showed a tumour with a maximum diameter of 12 cm, protruding into the oesophageal lumen. The patient remains stable and disease-free 18 months after tumour resection. The tumour was well demarcated with a glistening, gelatinous, white-yellowish cut surface. Microscopically, the tumour was primarily composed of spindle cells and mature adipocytes, sparsely intermingled with lipoblasts (figure 1A,B). Throughout most of the tumour, spindle cells had inconspicuous nuclear atypia, …