IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria

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Abstract
Significance: Upon enteropathogenic bacterial infection, cytokines orchestrate innate and adaptive immune activation that promotes barrier protection and pathogen control. Using Citrobacter rodentium , we defined a critical role for IL-36R signaling in driving early IL-23- and late IL-6-mediated IL-22 production, antimicrobial activity, and host protection. Our data show that the IL-36/IL-36R axis integrates innate and adaptive immune responses to afford host protection to enteropathogenic bacterial infection. These findings provide mechanistic insight into how the proinflammatory IL-36 pathway coordinates immunity and highlight the potential for targeting IL-36 cytokines and IL-36R in treating enteropathogenic bacterial infection.
Funding Information
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK120907)
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK107739)
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK107739)

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