MicroRNAs and Molecular Mechanisms of Neurodegeneration
Open Access
Abstract
During the last few years microRNAs (miRNAs) have emerged as key mediators of post-transcriptional and epigenetic regulation of gene expression. MiRNAs targets, identified through gene expression profiling and studies in animal models, depict a scenario where miRNAs are fine-tuning metabolic pathways and genetic networks in both plants and animals. MiRNAs have shown to be differentially expressed in brain areas and alterations of miRNAs homeostasis have been recently correlated to pathological conditions of the nervous system, such as cancer and neurodegeneration. Here, we review and discuss the most recent insights into the involvement of miRNAs in the neurodegenerative mechanisms and their correlation with significant neurodegenerative disorders.Keywords
This publication has 129 references indexed in Scilit:
- Inclusion of a portion of the native SNCA 3′UTR reduces toxicity of human S129A SNCA on striatal‐projecting dopamine neurons in rat substantia NigraDevelopmental Neurobiology, 2011
- In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of MelanomaCell, 2011
- Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAsCell, 2011
- Neural Stem Cell Gene Therapy Ameliorates Pathology and Function in a Mouse Model of Globoid Cell LeukodystrophyStem Cells, 2011
- A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?Cell, 2011
- Allele-Selective Inhibition of Huntingtin Expression by Switching to an miRNA-like RNAi MechanismChemistry & Biology, 2010
- Posttranscriptional Regulation of MicroRNA Biogenesis in AnimalsMolecular Cell, 2010
- Origins and Mechanisms of miRNAs and siRNAsCell, 2009
- Variation in the miRNA-433 Binding Site of FGF20 Confers Risk for Parkinson Disease by Overexpression of α-SynucleinThe American Journal of Human Genetics, 2008
- The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in DrosophilaCell, 2007