Bevacizumab therapy for POEMS syndrome

Authors:
  • ABAshraf Badros
    Ashraf Badros
  • NPNeil Porter
    Neil Porter
  • AZAnn Zimrin
    Ann Zimrin
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Abstract
A 52-year-old woman presented with progressive sensory and motor neuropathy for 2 years that left her bedridden. She had lost 30 kg and had a Karnofsky score of 40. She had received empiric intravenous immunoglobulin and steroids with no improvement. She was admitted with aspiration pneumonia. She had severe wasting and weakness in distal and proximal muscles, stocking-glove painful paresthesias, absent deep tendon reflexes, and weak gag reflex. She had extensive edema and hyperpigmented skin patches. She also had significant ascites, pleural and pericardial effusions, and hepatomegaly.