Iron-Catalyzed Cycloaddition of Amides and 2,3-Diaryl-2H-azirines To Access Oxazoles via C–N Bond Cleavage
- 14 January 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 86 (3) , 2957-2964
Abstract
A novel and efficient iron-catalyzed cycloaddition reaction using readily available 2,3-diaryl-2H-azirines and primary amides is reported. A wide range of trisubstituted oxazoles could be achieved in good yields with good functional group compatibility. In this transformation, two C–N bonds were cleaed and new C–N and C–O bonds were formed.Keywords
Funding Information
- Baoji University of Arts And Sciences (ZK2018057)
- Scientific Research Foundation of Shaanxi Provincial Key Laboratory (19JS006)
- China Postdoctoral Science Foundation (2019T120936)
- Natural Science Foundation of Shaanxi Province (2018JQ2031)
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