Effects of PPARγ ligands on TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells
Open Access
- 23 February 2010
- journal article
- research article
- Published by Springer Nature in Respiratory Research
- Vol. 11 (1) , 21
Abstract
Transforming growth factor β1 (TGF-β1)-mediated epithelial mesenchymal transition (EMT) of alveolar epithelial cells (AEC) may contribute to lung fibrosis. Since PPARγ ligands have been shown to inhibit fibroblast activation by TGF-β1, we assessed the ability of the thiazolidinediones rosiglitazone (RGZ) and ciglitazone (CGZ) to regulate TGF-β1-mediated EMT of A549 cells, assessing changes in cell morphology, and expression of cell adhesion molecules E-cadherin (epithelial cell marker) and N-cadherin (mesenchymal cell marker), and collagen 1α1 (COL1A1), CTGF and MMP-2 mRNA.Keywords
This publication has 55 references indexed in Scilit:
- Hepatocyte Growth Factor Inhibits Epithelial to Myofibroblast Transition in Lung Cells via Smad7American Journal of Respiratory Cell and Molecular Biology, 2009
- Peroxisome proliferator‐activated receptor‐γ abrogates Smad‐dependent collagen stimulation by targeting the p300 transcriptional coactivatorThe FASEB Journal, 2009
- Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosisJournal of Clinical Investigation, 2008
- Peroxisome Proliferator-activated Receptor γ Down-regulates Follistatin in Intestinal Epithelial Cells through SP1Journal of Biological Chemistry, 2008
- Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–β SignalingAmerican Journal of Respiratory Cell and Molecular Biology, 2008
- Peroxisome Proliferator Activated Receptor Ligands as Regulators of Airway Inflammation and Remodelling in Chronic Lung DiseasePPAR Research, 2007
- Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cellsRespiratory Research, 2007
- Expression profiling of genes regulated by TGF-beta: Differential regulation in normal and tumour cellsBMC Genomics, 2007
- The Role of PPARs in Lung FibrosisPPAR Research, 2007
- Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrixProceedings of the National Academy of Sciences, 2006