Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic
Authors:
- 1 December 1996
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 70 (12) , 8614-8623
Abstract
A new rabbit calicivirus related to the rabbit hemorrhagic disease virus (RHDV) was identified. The new virus contains significant differences from the previously characterized RHDV isolates in terms of pathogenicity, viral titer, tropism, and primary sequence of the structural protein. Cross-protection experiments, antigenic data, and sequence comparisons demonstrate that the new virus is more closely related to RHDV than to the European brown hare syndrome virus, another member of the caliciviruses of the lagomorph group. The existence of a nonpathogenic calicivirus, which we propose to name rabbit calicivirus (RCV), provides an explanation for the early discrepancies found in the course of serological surveys of the rabbit population in European countries.Keywords
This publication has 23 references indexed in Scilit:
- Sindbis virus pathogenesis: phenotypic reversion of an attenuated strain to virulence by second-site intragenic suppressor mutationsJournal of General Virology, 1993
- Two Novel Single Amino Acid Syncytial Mutations in the Carboxy Terminus of Glycoprotein B of Herpes Simplex Virus Type 1 Confer a Unique Pathogenic PhenotypeVirology, 1993
- Haemorrhagic disease of lagomorphs: evidence for a calicivirusVeterinary Microbiology, 1992
- Location of monoclonal antibody binding sites in the capsid protein of feline calicivirusJournal of General Virology, 1992
- European brown hare syndrome in the U.K.; a calicivirus related to but distinct from that of viral haemorrhagic disease in rabbitsArchives of Virology, 1992
- Nucleotide sequence of the capsid protein gene of two serotypes of San Miguel sea lion virus: Identification of conserved and non-conserved amino acid sequences among calicivirus capsid proteinsVirus Research, 1992
- Genomic and subgenomic RNAs of rabbit hemorrhagic disease virus are both protein-linked and packaged into particlesVirology, 1991
- Neutralizing epitopes of feline calicivirusArchives of Virology, 1991
- Diagnosis of viral haemorrhagic disease of rabbits and the European brown hare syndromeScientific and Technical Review, 1991
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979