Alcohols as Electrophiles in C-C Bond‐Forming Reactions: The Hydrogen Autotransfer Process
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- 16 March 2007
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 46 (14) , 2358-2364
Abstract
The hydrogen autotransfer process involves an initial oxidative hydrogen elimination, followed by different types of reactions, and is completed with a reductive hydrogen addition to give the final product. The sequence allows the alkylation of different nucleophilic agents using environmentally benign alcohols as electrophiles, mild conditions, and soft bases, with water produced as the only waste material. Recent examples of modulating the organometallic catalyst have also lent themselves to expansion of the range of available substrates, as described in this Minireview.Keywords
This publication has 77 references indexed in Scilit:
- Efficient Solvent-Free Selective Monoalkylation of Arylacetonitriles with Mono-, Bis-, and Tris-primary Alcohols Catalyzed by a Cp*Ir ComplexThe Journal of Organic Chemistry, 2006
- Value of sustainability: perspectives of a chemical manufacturing siteClean Technologies and Environmental Policy, 2005
- Selective synthesis of 2-ethyl-1-hexanol from n-butanol through the Guerbet reaction by using bifunctional catalysts based on copper or palladium precursors and sodium butoxideJournal of Molecular Catalysis A: Chemical, 2004
- Catalytic Electronic Activation: Indirect “Wittig” Reaction of AlcoholsAngewandte Chemie, 2002
- Multicomponent domino reactions for the synthesis of biologically active natural products and drugsMedicinal Research Reviews, 2000
- The Atom Economy—A Search for Synthetic EfficiencyScience, 1991
- Reactions of acetophenone with alcohols over oxide catalysts: Alkylation of ketones by alcoholsJournal of Catalysis, 1989
- C-Alkylation of active methylene compounds by means of alcohols. VI. Facile monoalkylation of phenylacetonitrileThe Journal of Organic Chemistry, 1971
- Disproportionative Condensations. I. Modified Guerbet ReactionsJournal of the American Chemical Society, 1954
- Polymerisations‐Erscheinungen unter der gemeinschaftlichen Einwirkung von Aluminiumoxyd und metallischem Eisen bei hohen Temperaturen und DruckenBerichte der deutschen chemischen Gesellschaft (A and B Series), 1925