Myocardial Perfusion Imaging with Radioactive-Labeled Particles Injected Directly into the Coronary Circulation of Patients with Coronary Artery Disease

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Abstract
Macroaggregated serum albumin (MAA) particles labeled with 131 iodine ( 131 I) or similar particles-labeled with 99m technetium ( 99m Tc) or both types were injected directly into the coronary circulation of 29 patients at the time of conventional coronary arteriography. Radionuclide images of the distribution of these small (10-60 µ) biodegradable particles in the small vessels of the heart wall were made with a commercial Anger-type scintillation camera in much the same way as routine pulmonary perfusion scans are made. The resulting images depicted the relative regional distribution of blood flow to the myocardium in these patients suspected of having coronary artery disease. The myocardial perfusion images were of good quality and allowed gross assessment of perfusion by way of each major coronary artery. This was done by injecting 99m Tc-labeled particles into the left coronary artery and 131 I-MAA into the right coronary artery through the coronary artery catheter. Separate or composite images of the relative small vessel perfusion via each vessel injected were obtained by electronic pulse-height discrimination. No untoward reactions followed the intracoronary injection of the labeled particles. From our preliminary experience, we conclude that myocardial perfusion imaging in conjunction with coronary arteriography may prove to be a valuable diagnostic tool in the evaluation of the regional vascular supply to the heart in patients with coronary artery disease.

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