Nocturnal Rapid Eye Movement Sleep Latency for Identifying Patients With Narcolepsy/Hypocretin Deficiency
Open Access
- 1 July 2013
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Neurology
- Vol. 70 (7) , 891-902
Abstract
The association of excessive daytime sleepiness with cataplexy (episodes of muscle weakness triggered by emotions) has traditionally been used to define narcolepsy.1,2 In 1960, it was found that during nocturnal polysomnography (NPSG), 50% of cases have rapid transitions from wake to rapid eye movement (REM) sleep (sleep-onset REM periods [SOREMPs]).3,4 The Multiple Sleep Latency Test (MSLT), a test that allows 4 to 5 daytime nap opportunities for sleep onset and SOREMPs, was subsequently developed to increase sensitivity. A mean sleep latency (MSL) of 8 minutes or less and 2 or more SOREMPs is considered diagnostic for narcolepsy.2 Positive MSLT results have been reported in 2% to 4% of the population.5,6Keywords
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