Double-stranded RNA activates type I interferon secretion in glomerular endothelial cells via retinoic acid-inducible gene (RIG)-1
- 16 July 2009
- journal article
- Published by Oxford University Press (OUP) in Nephrology Dialysis Transplantation
- Vol. 24 (11) , 3312-3318
Abstract
Background. The molecular pathomechanisms by which viral infections trigger glomerulonephritis remain elusive. In the glomerulus, glomerular endothelial cells (GEnC) first interact with circulating viral particles; hence, we hypothesized that viral RNA, a known inducer of type I interferons and cytokines in dendritic cells, would also elicit proinflammatory antiviral reponses in GEnC.Keywords
This publication has 44 references indexed in Scilit:
- Orchestrating the orchestrators: chemokines in control of T cell trafficNature Immunology, 2008
- Interferon-inducible antiviral effectorsNature Reviews Immunology, 2008
- Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNANature, 2008
- Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi’s sarcoma cell lineCellular Immunology, 2007
- Small self-RNA generated by RNase L amplifies antiviral innate immunityNature, 2007
- Interferon-β and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signallingClinical and Experimental Immunology, 2006
- RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-PhosphatesScience, 2006
- 5'-Triphosphate RNA Is the Ligand for RIG-IScience, 2006
- Pathogen Recognition and Innate ImmunityCell, 2006
- The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesNature Immunology, 2004