Transition Metal‐Free Synthesis of 3‐Alkynylpyrrole‐2‐carboxylates via Michael Addition/Intramolecular Cyclodehydration
- 2 June 2016
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 358 (12) , 1897-1902
Abstract
A transition metal‐free and efficient method for the synthesis of 3‐alkynylpyrrole‐2‐carboxylates from diynones and glycine esters or 2‐aminoacetophenone hydrochloride has been developed. This transformation provides a large range of substituted pyrroles in good to excellent yields with the elimination of water as the only by‐product. The detailed mechanistic studies elucidated that this transformation involves a Michael addition/intramolecular cyclodehydration process. magnified imageKeywords
Funding Information
- Ministry of Education of China (IRT1225)
- National Natural Science Foundation of China (21362002, 41465009 and 81260472)
- Guangxi Natural Science Foundation of China (2014GXNSFDA118007)
- State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (CMEMR2014A02 and CMEMR2012A20)
- BAGUI Scholar Program
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