Inhibin as a Marker for Granulosa-Cell Tumors

Authors:
  • JBJoke Bouma
    Joke Bouma
  • MBMohan Bangah
    Mohan Bangah
  • MKMindert Krans
    Mindert Krans
  • HBHenk W.A. De Bruijn
    Henk W.A. De Bruijn
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Abstract
Inhibin is a peptide hormone normally produced by ovarian granulosa cells. It reaches a peak of 772±38 U per liter in the follicular phase of the menstrual cycle and is undetectable in the serum of menopausal women. To determine whether measurements of serum inhibin levels would provide a biochemical marker of the presence or progression of ovarian granulosa-cell tumors and their metastases, we measured the serum immunoreactive inhibin concentrations in six women with such tumors. Three women had been treated by hysterectomy and bilateral salpingo-oophorectomy.

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