Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain
Authors:
- 16 March 2001
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 15 (2) , 167-169
Abstract
The effects of benzophenanthridine alkaloids, such as sanguinarine and chelidonine, on monoamine oxidase (MAO) activity in mouse brain were investigated. Sanguinarine showed an inhibitory effect on MAO activity in a concentration dependent manner (53.4% inhibition at 25 µM). However, chelidonine did not inhibit MAO activity. The IC50 value of sanguinarine was 24.5 µM. Sanguinarine inhibited non‐competitively MAO activity using kynuramine as a substrate. The Ki value for sanguinarine was 22.1 µM. These results suggest that sanguinarine partially contributes to the regulation of catecholamine content. Copyright © 2001 John Wiley & Sons, Ltd.Keywords
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