To prevent a second drug resistance crisis due to an increasing resistance of pathogenic fungi to most current antifungals, new classes of antifungal drugs are urgently needed. The authors of this study report the discovery of a high number of metal-containing compounds, which were screened by the Community for Open Drug Discovery (CO-ADD), to have potent antimicrobial activity towards strains of Candida and Cryptococcus spp and low, if any, toxicity in a moth larva model. These findings make a strong case that a more systematic and thorough study of metal-based compounds for antifungal application is warranted.