The rate of decline of joint space width in patients with osteoarthritis of the knee: a systematic review and meta-analysis of randomized placebo-controlled trials of chondroitin sulfate
- 2 October 2008
- journal article
- conference paper
- Published by Informa Healthcare in Current Medical Research and Opinion
- Vol. 24 (11) , 3029-3035
Abstract
Background: Chondroitin sulfate has been shown to relieve pain and improve functional limitation in patients with osteoarthritis (OA) of the knee in numerous clinical trials and meta-analyses. Its role as a potential structure-modifying drug for knee OA, however, remains controversial.Objective: To perform a meta-analysis of randomized double-blind placebo-controlled clinical trials to assess the efficacy of chondroitin sulfate as a structure-modifying drug for knee OA.Research design and methods: A Medline search was conducted from 1996 through 2007 and five articles that reported results from three trials were identified; one additional trial was identified through review of presentations at annual rheumatology meetings. There was no evidence of heterogeneity across the trials and results were pooled using a fixed effects meta-analysis.Results: Pooled results demonstrated a small significant effect of chondroitin sulfate on the reduction in rate of decline in minimum joint space width of 0.07 mm...Keywords
This publication has 17 references indexed in Scilit:
- Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissuesAnnals of the Rheumatic Diseases, 2008
- Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analysesCurrent Medical Research and Opinion, 2008
- OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelinesOsteoarthritis and Cartilage, 2008
- Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: A randomized, controlled trialArthritis & Rheumatism, 2005
- Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo11Principal Investigators: D. Uebelhart, MD, Assistant Professor; M. Malaise, MD, Professor, R. Marcolongo, MD, Professor; E. Vignon, MD, Professor. Co-Investigators: M. Piperno, MD, Head Physician; E. Mailleux, MD, Head Physician; A. Fioravanti, MD, Head Physician; L. Matoso, MD, Physician; Statistical analysis: F. DeVathaire, PhD, Professor; Radiological analysis: E. Vignon, MD, Professor.Osteoarthritis and Cartilage, 2004
- Measuring inconsistency in meta-analysesBMJ, 2003
- Measurement of radiographic joint space width in the tibiofemoral compartment of the osteoarthritic knee: Comparison of standing anteroposterior and Lyon Schuss viewsArthritis & Rheumatism, 2003
- Quantificative evaluation of joint space width in femorotibal osteoarthritis: comparison of three radiographic viewsOsteoarthritis and Cartilage, 1998
- Is conventional radiography suitable for evaluation of a disease-modifying drug in patients with knee osteoarthritis?Osteoarthritis and Cartilage, 1997
- Assessing the quality of reports of randomized clinical trials: Is blinding necessary?Controlled Clinical Trials, 1996