Synthesis of Eel-Calcitonin and [Asu1,7]-Eel-Calcitonin: Contribution of the disulfide bond to the hormonal activity
Authors:
- 1 September 1976
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 32 (9) , 1104-1106
Abstract
Eel-calcitonin and its [Asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.Keywords
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