In silico optimization of regenerative cell therapy in the infarcted human ventricles to mitigate arrhythmic burden
Open Access
- 9 July 2026
- journal article
- Published by Elsevier in Stem Cell Reports
- Vol. 21 (8) , 103007
Abstract
No abstract availableKeywords
Funding Information
- Engineering and Physical Sciences Research Council
- Bristol-Myers Squibb
- British Heart Foundation
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- AstraZeneca
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
This publication has 68 references indexed in Scilit:
- An automated computational pipeline for generating large-scale cohorts of patient-specific ventricular models in electromechanical in silico trialsComputer Methods and Programs in Biomedicine, 2026
- Costs of Drug Development and Research and Development Intensity in the US, 2000-2018JAMA Network Open, 2024
- Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibilityCPT: Pharmacometrics & Systems Pharmacology, 2021
- All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug EvaluationBiophysical Journal, 2020
- A rule‐based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tractsInternational Journal for Numerical Methods in Biomedical Engineering, 2019
- Performance evaluation of GPU parallelization, space‐time adaptive algorithms, and their combination for simulating cardiac electrophysiologyInternational Journal for Numerical Methods in Biomedical Engineering, 2017
- Na/K pump regulation of cardiac repolarization: insights from a systems biology approachPflügers Archiv - European Journal of Physiology, 2013
- Sodium-Calcium Exchange Is Essential for Effective Triggering of Calcium Release in Mouse HeartBiophysical Journal, 2010
- Na+/K+ ATPase and its functional coupling with Na+/Ca2+ exchanger in mouse embryonic stem cells during differentiation into cardiomyocytesCell Calcium, 2005
- Inhomogeneous Transmural Conduction During Early Ischaemia in Patients with Coronary Artery DiseaseJournal of Molecular and Cellular Cardiology, 2000