Inwardly rectifying potassium channels (KIR) in GtoPdb v.2025.4

Authors:
  • PSPaul A. Slesinger
    Paul A. Slesinger
  • SSSusumu Seino
    Susumu Seino
  • HSHenry Sackin
    Henry Sackin
  • WPWade L. Pearson
    Wade L. Pearson
  • LPLawrence G. Palmer
    Lawrence G. Palmer
  • CNColin G. Nichols
    Colin G. Nichols
  • TMTakashi Miki
    Takashi Miki
  • MLMichel Lazdunski
    Michel Lazdunski
  • YKYoshihisa Kurachi
    Yoshihisa Kurachi
  • YKYoshihiro Kubo
    Yoshihiro Kubo
Open Access
Publisher website
Google Scholar
Abstract
The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).