Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gut
Authors:
- J.J. HolstJHJ.J. Holst
- C. ØrskovCØC. Ørskov
- O. Vagn NielsenONO. Vagn Nielsen
- T.W. SchwartzTST.W. Schwartz
- 26 January 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 211 (2) , 169-174
Abstract
By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78–107 as suggested by chromatography and determination of its N‐terminal sequence. Natural and synthetic proglucagon 78–107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78–107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.Keywords
This publication has 19 references indexed in Scilit:
- Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequenceFEBS Letters, 1986
- The processing of peptide precursorsFEBS Letters, 1986
- Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic isletsDiabetologia, 1985
- How glucagon-like is glucagon-like peptide-1?Diabetologia, 1984
- Hamster preproglucagon contains the sequence of glucagon and two related peptidesNature, 1983
- [36] High-sensitivity sequencing with a gas-phase sequenator1983
- Radioreceptorassays for Glucagon1983
- Mechanism of C-terminal amide formation by pituitary enzymesNature, 1982
- Relationship of glicentin to proglucagon and glucagon in the porcine pancreasNature, 1981
- Gastric Inhibitory Polypeptide (GIP) and Insulin Release after Small-Bowel Resection in ManScandinavian Journal of Gastroenterology, 1980