Multifocal perineural invasion is a better prognosticator than depth of invasion in oral squamous cell carcinoma
Authors:
- Shaheen HasmatSHShaheen Hasmat
- Carsten PalmeCPCarsten Palme
- 5 September 2019
- journal article
- research article
- Published by Wiley in Head & Neck
- Vol. 41 (11) , 3992-3999
Abstract
Objectives: Prognostic significance of perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) characterized as unifocal and multifocal was compared to depth of invasion (DOI) and extranodal extension (ENE).Materials and Methods: Univariable and multivariable analyses of 861 consecutive patients with OSCC undergoing treatment between 1995 and 2018 were performed, with local failure (LF) and disease‐specific mortality (DSS) as the primary endpoints.Results: After adjusting for other adverse histopathological factors and adjuvant therapy, multifocal PNI was associated with a greater risk of LF (P = .01) and DSS (P = 0.02) compared to DOI. The effect of multifocal PNI was comparable to the effect of nodal metastases without ENE (P = 0.02). LF and DSS were not improved by the administration of adjuvant radiotherapy within unifocal or multifocal PNI groups.Conclusion: Multifocal PNI is associated with a greater risk of death in OSCC than DOI. Its effect is comparable to that of nodal metastases (without ENE).Keywords
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