Approximate D-optimal designs of experiments on the convex hull of a finite set of information matrices

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Abstract
In the paper we solve the problem of D ℋ-optimal design on a discrete experimental domain, which is formally equivalent to maximizing determinant on the convex hull of a finite set of positive semidefinite matrices. The problem of D ℋ-optimality covers many special design settings, e.g., the D-optimal experimental design for multivariate regression models. For D ℋ-optimal designs we prove several theorems generalizing known properties of standard D-optimality. Moreover, we show that D ℋ-optimal designs can be numerically computed using a multiplicative algorithm, for which we give a proof of convergence. We illustrate the results on the problem of D-optimal augmentation of independent regression trials for the quadratic model on a rectangular grid of points in the plane.

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