Aqueous Solubilization of Fullerenes Using Poly(amidoamine) Dendrimers Bearing Cyclodextrin and Poly(ethylene Glycol)
Authors:
- 10 October 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 19 (11) , 2280-2284
Abstract
Fullerene has a unique structure and notable chemical and physical properties, which have been studied in diverse fields including biological applications. The extremely poor solubility of fullerenes in water limits their usage for biomedical applications. In this study, we synthesized polyamidoamine dendrimers having both β-cyclodextrin (CD) and poly(ethylene glycol) (PEG) and characterized the resulting dendrimers by 1H NMR, IR, and gel permeation chromatography. We prepared 2.8 μM of aqueous fullerene solutions using these dendrimers. The clustering effect of CD and PEG at the surface of the dendrimer might be crucial for the solubilization of fullerene.Keywords
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