The effect of phototherapy on the expression of innate immunity genes in patients with psoriasis

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Abstract
BACKGROUND: Phototherapy is one of the most effective methods in the treatment of psoriasis, but the mechanism of its action on innate immunity has not been studied. AIM: Investigation of the local expression profile of innate immunity factors in patients with psoriasis during phototherapy. MATERIALS AND METHODS: The study included 31 patients diagnosed with inpatient psoriasis vulgaris. The material for the study was obtained from areas of affected and unaffected skin. Patients with vulgar psoriasis received a course of UVB-311 nm phototherapy lasting from 5 to 7 weeks with a total dose of 35.2 to 44.6 J/cm2. There were 30 healthy people in the control group. Gene expression analysis was performed before treatment and at the end of the phototherapy course. The data obtained were statistically processed. RESULTS: According to the results of the study, gene expression data were obtained: for example, increased expression of the TLR2 and TLR9 genes was observed in the main group after treatment, as well as in samples of unaffected skin from patients. The increased level of the TLR4 gene expression was registered in unaffected skin samples from patients with psoriasis. The expression of the β-defensin 1 gene was elevated in unaffected skin and post-treatment skin. For the cathelicidin gene, there is a difference between the groups of affected and unaffected skin samples before treatment. The expression level of the IL-13 gene was higher before treatment. CONCLUSION: The revealed local imbalance of factors of innate immunity can lead to a more severe course of the disease. The course of phototherapy leads to normalization of the expression profile of receptor and effector molecules of innate immunity, which leads to a stable positive clinical effect.

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