DESENSITIZATION OF THE ACETYLCHOLINE RECEPTOR OF DENERVATED RAT SOLEUS MUSCLE AND THE EFFECT OF CALCIUM
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Open Access
- 1 May 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 69 (1) , 91-98
Abstract
Desensitization of the extrajunctional acetylcholine receptors of denervated rat soleus muscle has been studied by evoking iontophoretic acetylcholine potentials at a high frequency (10 Hz). Desensitization occurred with a slow and at least one fast component. Increasing the dose of acetylcholine decreased the half time of onset of desensitization, but did not alter recovery half time. Alteration of external calcium between 0 and 50 mm, or perfusion with agents which increase intracellular calcium such as 2,4‐dinitrophenol and the calcium ionophores, X537A and A23187, did not alter desensitization half time. The cholinoceptor agonists acetylcholine, acetylthiocholine, tetramethylammonium and phenyltrimethylammonium all caused desensitization at the same rate.Keywords
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