Elastase Release from Human Alveolar Macrophages: Comparison Between Smokers and Nonsmokers
Authors:
- 21 October 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 198 (4314) , 313-314
Abstract
Alveolar macrophages from smokers, in contrast to those of nonsmokers, release elastase into serum-free culture medium. Since enzymes that digest elastin produce pulmonary emphysema in experimental animals, release of elastase by alveolar macrophages from smokers suggests that these cells are important in the pathogenesis of emphysema of smokers.Keywords
This publication has 13 references indexed in Scilit:
- Elastase secretion by stimulated macrophages. Characterization and regulation.Journal of Experimental Medicine, 1975
- Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects.Journal of Clinical Investigation, 1975
- The synthesis and analytical use of a highly sensitive and convenient substrate of elastaseBiochemical Medicine, 1974
- Pathologic Changes in the Peripheral Airways of Young Cigarette SmokersNew England Journal of Medicine, 1974
- The Neutral Proteases of Human GranulocytesEuropean Journal of Biochemistry, 1974
- Interrelationships between the Human Alveolar Macrophage and Alpha-1-AntitrypsinJournal of Clinical Investigation, 1973
- Emphysema in apparently healthy adults. Smoking, age, and sexJAMA, 1973
- Anatomic and Histologic Changes of Early EmphysemaChest, 1971
- Elastase-Like, Esteroprotease Activity in Human and Rabbit Alveolar Macrophage GranulesExperimental Biology and Medicine, 1971
- Experimental EmphysemaArchives of Environmental Health: An International Journal, 1965