Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801
Authors:
- Fabio FumagalliFFFabio Fumagalli
- Raffaella MolteniRMRaffaella Molteni
- Francesco BedogniFBFrancesco Bedogni
- Massimo GennarelliMGMassimo Gennarelli
- Jorge PerezJPJorge Perez
- Giorgio RacagniGRGiorgio Racagni
- Marco A. RivaMarco A. Riva
- 1 September 2004
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 15 (13) , 2109-2112
Abstract
Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.Keywords
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