Agglutinin Production in Normal, Sublethally Irradiated, and Lethally Irradiated Mice Treated with Mouse Bone Marrow

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Abstract
Summary: Maximum agglutinin production was attained when the mice were 12 weeks of age. The optimum antigen dose to induce the maximum agglutinin response was found to be 1 ml of a 1.0% RBC suspension. Isologous bone marrow suspension protected 95% of the lethally x-irradiated mice (950 r). The ability to produce sheep agglutinin was recovered 30 days after the lethal irradiation-bone marrow treatment, whereas 60 days were required to produce rat agglutinin.