Engineering aldolases as biocatalysts
Open Access
- 1 April 2014
- journal article
- review article
- Published by Elsevier in Current Opinion in Chemical Biology
- Vol. 19 (100) , 25-33
Abstract
No abstract availableKeywords
Funding Information
- Innovative Medicines Initiative Joint Undertaking (115360)
- European Union's Seventh Framework Programme (FP7/2007-2013)
This publication has 48 references indexed in Scilit:
- Robust design and optimization of retroaldol enzymesProtein Science, 2012
- Improving upon Nature: Active Site Remodeling Produces Highly Efficient Aldolase Activity toward Hydrophobic Electrophilic SubstratesBiochemistry, 2012
- Directed evolution of a pyruvate aldolase to recognize a long chain acyl substrateBioorganic & Medicinal Chemistry, 2011
- Optimizing non-natural protein function with directed evolutionCurrent Opinion in Chemical Biology, 2011
- Replacement of a Phenylalanine by a Tyrosine in the Active Site Confers Fructose-6-phosphate Aldolase Activity to the Transaldolase of Escherichia coli and Human OriginJournal of Biological Chemistry, 2008
- Directed evolution of aldolases for exploitation in synthetic organic chemistryArchives of Biochemistry and Biophysics, 2008
- De Novo Computational Design of Retro-Aldol EnzymesScience, 2008
- Mutagenesis of the phosphate‐binding pocket of KDPG aldolase enhances selectivity for hydrophobic substratesProtein Science, 2007
- In vivo selection for the directed evolution of l-rhamnulose aldolase from l-rhamnulose-1-phosphate aldolase (RhaD)Bioorganic & Medicinal Chemistry, 2007
- Directed evolution of an industrial biocatalyst: 2‐deoxy‐D‐ribose 5‐phosphate aldolaseBiotechnology Journal, 2006