Association of Depression and Anxiety With the Accumulation of Chronic Conditions

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Abstract
Depression and anxiety are associated with an increased risk of multimorbidity and premature death from natural causes,1-3 and may be associated with a more rapid accumulation of chronic medical conditions commonly observed in older people, a proxy for accelerated aging.4-6 Although a direct link between depression, anxiety, and accelerated aging has not been demonstrated, there is increasing evidence of shared biological mechanisms between depression and chronic conditions known to occur later in life,7 as well as measures of cellular aging.8

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