Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Authors:
- Christopher FröhlichCFChristopher Fröhlich
- João A. GamaJGJoão A. Gama
- Klaus HarmsKHKlaus Harms
- Viivi H. A. HirvonenVHViivi H. A. Hirvonen
- Bjarte A. LundBLBjarte A. Lund
- Marc W. van der KampMKMarc W. van der Kamp
- Pål J. JohnsenPJPål J. Johnsen
- Ørjan SamuelsenØSØrjan Samuelsen
- Hanna-Kirsti S. LeirosHLHanna-Kirsti S. Leiros
Open Access
- 28 April 2021
- journal article
- research article
- Published by American Society for Microbiology in mSphere
- Vol. 6 (2)
Abstract
Very low antibiotic concentrations have been shown to drive the evolution of antimicrobial resistance. While substantial progress has been made to understand the driving role of low concentrations during resistance development for different antimicrobial classes, the importance of β-lactams, the most commonly used antibiotics, is still poorly studied.Keywords
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Funding Information
- Norges Forskningsråd (273332/2018)
- Helse Nord RHF (SFP1292-16)
- Joint Programming Initiative on Antimicrobial Resistance (271176/H10)
- General Medical Council (MR/N0137941/1)
- UKRI | Biotechnology and Biological Sciences Research Council (BB/M026280/1)
- Norges Forskningsråd (262695 and 274858)
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