Effects of interleukin-15 on autophagy regulation in the skeletal muscle of mice
- 1 March 2024
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Endocrinology and Metabolism
- Vol. 326 (3) , E326-E340
Abstract
IL-15 gene deficiency can decrease autophagy induction. However, although IL-15 overexpression induced a decrease in muscle mass, it led to an improvement in muscle quality. Based on these results, understanding the role of IL-15 in regulating autophagy pathways within skeletal muscle may lead to the development of therapies for the autophagy-induced regulation of skeletal muscle mass and cellular quality control.Keywords
Funding Information
- MEXT | Japan Society for the Promotion of Science (21K17481)
- Japan Society for the Promotion of Science (20K07802)
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