MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment
- 1 August 2017
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 61 (8)
Abstract
The spread of mcr-1 -encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1 -encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.Keywords
This publication has 15 references indexed in Scilit:
- Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in GermanyThe Lancet Infectious Diseases, 2016
- Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coliThe Lancet Infectious Diseases, 2016
- Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological studyThe Lancet Infectious Diseases, 2016
- Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015Eurosurveillance, 2015
- The Harvest suite for rapid core-genome alignment and visualization of thousands of intraspecific microbial genomesGenome Biology, 2014
- Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly ImprovementPLOS ONE, 2014
- IS 1R -Mediated Plasticity of IncL/M Plasmids Leads to the Insertion of bla OXA-48 into the Escherichia coli ChromosomeAntimicrobial Agents and Chemotherapy, 2014
- Assembling Single-Cell Genomes and Mini-Metagenomes From Chimeric MDA ProductsJournal of Computational Biology, 2013
- The C lermont
E
scherichia coli
phylo‐typing method revisited: improvement of specificity and detection of new phylo‐groupsEnvironmental Microbiology Reports, 2012
- Fast and accurate short read alignment with Burrows–Wheeler transformBioinformatics, 2009