Effects of a hemoregulatory peptide (HP5b) on erythroid and myelopoietic colony formation in vitro

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Abstract
A hemoregulatory peptide (HP5b) associated with mature human granulocytes has been investigated for inhibitory effects on murine hemopoietic stem cells in vitro. Both highly purified peptide from natural sources and a synthetic analog peptide have been investigated in parallel. Strong inhibitory effects were found on myelopoietic colony formation in the dose range 10−13‐10−5 mol/l. On exceeding this dose, the inhibitory effect disappeared. Moderate to slight inhibitory effects on erythroid colony formation (BFU‐E and CFU‐E) from adult animals were only seen in 1000 x the optimal doses for myelopoiesis. No effect was found on CFU‐E from fetal liver. The peptide thus has a selective effect on myelopoiesis in a certain dose range. A regulatory mechanism for the peptide on hemopoiesis is proposed.

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