Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging
- 1 April 2021
- journal article
- research article
- Published by Elsevier in Neurobiology of Aging
- Vol. 100, 48-58
Abstract
No abstract availableKeywords
Funding Information
- National Center for Complementary and Integrative Health
- U.S. Department of Veterans Affairs
This publication has 75 references indexed in Scilit:
- Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2–ARE pathwayFree Radical Biology and Medicine, 2013
- Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanismNeurological Sciences, 2012
- Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeuticsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
- Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cellsActa Pharmacologica Sinica, 2012
- Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in MiceAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's diseaseProceedings of the National Academy of Sciences, 2009
- Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's diseaseTrends in Molecular Medicine, 2008
- Expression of Nrf2 in Neurodegenerative DiseasesJournal of Neuropathology & Experimental Neurology, 2007
- Models of visuospatial and verbal memory across the adult life span.Psychology and Aging, 2002
- Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslaticaPhytomedicine, 2000