The Insulin Receptor Substrate (IRS)-1 Pleckstrin Homology Domain Functions in Downstream Signaling
Authors:
- Inna VainshteinIVInna Vainshtein
- Kristina S. KovacinaKKKristina S. Kovacina
- Richard A. RothRRRichard A. Roth
Open Access
- 1 March 2001
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 276 (11) , 8073-8078
Abstract
No abstract availableKeywords
This publication has 30 references indexed in Scilit:
- Different Subcellular Localization and Phosphoinositides Binding of Insulin Receptor Substrate Protein Pleckstrin Homology DomainsMolecular Endocrinology, 2000
- The PI3K‒PDK1 connection: more than just a road to PKBBiochemical Journal, 2000
- Intracellular Localization of Phosphatidylinositide 3-kinase and Insulin Receptor Substrate-1 in Adipocytes: Potential Involvement of a Membrane SkeletonJournal of Cell Biology, 1998
- Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 TranslocationJournal of Biological Chemistry, 1996
- The Pleckstrin Homology Domain Is the Principle Link between the Insulin Receptor and IRS-1Journal of Biological Chemistry, 1996
- Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I ReceptorsJournal of Biological Chemistry, 1996
- Interaction between the Insulin Receptor and Its Downstream EffectorsJournal of Biological Chemistry, 1996
- Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BNature, 1995
- PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding SpecificitiesJournal of Biological Chemistry, 1995
- Tyrosine Phosphorylation of Insulin Receptor Substrate-1 in Vivo Depends upon the Presence of Its Pleckstrin Homology RegionJournal of Biological Chemistry, 1995