Supplementary Figures S1 - S2 from An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant–Driven Breast Cancer

Authors:
  • AHAriella B. Hanker
    Ariella B. Hanker
  • MBMonica Red Brewer
    Monica Red Brewer
  • JSJonathan H. Sheehan
    Jonathan H. Sheehan
  • JKJames P. Koch
    James P. Koch
  • GSGregory R. Sliwoski
    Gregory R. Sliwoski
  • RNRebecca Nagy
    Rebecca Nagy
  • RLRichard Lanman
    Richard Lanman
  • MBMichael F. Berger
    Michael F. Berger
  • DHDavid M. Hyman
    David M. Hyman
  • DSDavid B. Solit
    David B. Solit
  • JHJie He
    Jie He
  • VMVincent Miller
    Vincent Miller

Abstract
Supplementary Figure S1. HER2L869R and HER3E928G cooperate to drive ERBB signaling output. Supplementary Figure S2. MG132 treatment restores expression of HER2T798I.