Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation
Authors:
- 2 May 2016
- journal article
- Published by Springer Nature in Nature Cell Biology
- Vol. 18 (6) , 668-675
Abstract
Chromosome missegregation can lead to p53 activation to block proliferation of aneuploid cells. Hinchcliffe, Dong and colleagues find that generation and spreading of a histone H3.3 Ser31 phosphorylation mark mediates this response.Keywords
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